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Max Planck Institute for Colloids and Interfaces

Peter Seeberger2

 

Peter Seeberger

Department of Biomolecular Systems
Max Plank Institute for Colloids and Interfaces
(Potsdam, Germany)
peter.seeberger@mpikg.mpg.de

                                   

Photo apardo

 

 

Alonso Pardo
MPI Fellow
Alonso.Pardo@mpikg.mpg.de

Project: “Expression of C-type lectin receptor-Fc fusion proteins and functional studies”

 

 

The core interests our research program currently address the following areas:

Automated oligosaccharide synthesis

  • Rapid access to monosaccharide by de-novo synthesis
  • New protecting groups
  • New Glycosylating Agents
  • New linkers for solid phase carbohydrate synthesis
  • Assembly of complex structures (in particular N-Glycans, O-Glycans)
  • Optimization of steps followingthe assembly, like deprotection, modification and conjugation

Total Synthesis of Biologically Important Oligosaccharides

  • Tumor-associated antigens
  • HIV-related oligosaccharides
  • Bacterial cell-surface antigens
  • N-linked glycoproteins

Chemical Synthesis and Biochemistry of Proteoglycans

  • Modular synthesis of heparin/heparan sulfates
  • Creation of heparin microarray
  • Optimization of the building blocks synthesis
  • Study of the SAR (structure-activity relationship) and the interactions between Proteoglycans and proteins
  • Automated synthesis of heparin fragments

Total Synthesis and Biological Activity of Glycosylphosphatidylinositols (GPIs)

  • Total syntheses of GPIs
  • Development of a synthetic GPI malarial vaccine
  • Elucidation of the biosynthesis of GPI
  • Immunological response to synthetic GPIs

Development of Cabohydrate-based Vaccines

  • A fully synthetic malaria vaccine
  • Leishmania vaccine
  • Synthetic HIV vaccine
  • Synthetic TB vaccine

Microreactors for Organic Synthesis

  • (Automated) Synthesis in continuous flow Microreactors
  • Photochemistry in Microflow reactors
  • Catalysis in Microreactors

Carbohydrate Microarrays

De novo synthesis

Nanoparticules and Colloidal Polymers

  • Quantum dots
  • Supramolecular dendrimers
  • Emulsion polymerization of nanoparticules