Max Planck Institute for Colloids and Interfaces

Peter Seeberger2


Peter Seeberger

Department of Biomolecular Systems
Max Plank Institute for Colloids and Interfaces
(Potsdam, Germany)


Photo apardo



Alonso Pardo
MPI Fellow

Project: “Expression of C-type lectin receptor-Fc fusion proteins and functional studies”



The core interests our research program currently address the following areas:

Automated oligosaccharide synthesis

  • Rapid access to monosaccharide by de-novo synthesis
  • New protecting groups
  • New Glycosylating Agents
  • New linkers for solid phase carbohydrate synthesis
  • Assembly of complex structures (in particular N-Glycans, O-Glycans)
  • Optimization of steps followingthe assembly, like deprotection, modification and conjugation

Total Synthesis of Biologically Important Oligosaccharides

  • Tumor-associated antigens
  • HIV-related oligosaccharides
  • Bacterial cell-surface antigens
  • N-linked glycoproteins

Chemical Synthesis and Biochemistry of Proteoglycans

  • Modular synthesis of heparin/heparan sulfates
  • Creation of heparin microarray
  • Optimization of the building blocks synthesis
  • Study of the SAR (structure-activity relationship) and the interactions between Proteoglycans and proteins
  • Automated synthesis of heparin fragments

Total Synthesis and Biological Activity of Glycosylphosphatidylinositols (GPIs)

  • Total syntheses of GPIs
  • Development of a synthetic GPI malarial vaccine
  • Elucidation of the biosynthesis of GPI
  • Immunological response to synthetic GPIs

Development of Cabohydrate-based Vaccines

  • A fully synthetic malaria vaccine
  • Leishmania vaccine
  • Synthetic HIV vaccine
  • Synthetic TB vaccine

Microreactors for Organic Synthesis

  • (Automated) Synthesis in continuous flow Microreactors
  • Photochemistry in Microflow reactors
  • Catalysis in Microreactors

Carbohydrate Microarrays

De novo synthesis

Nanoparticules and Colloidal Polymers

  • Quantum dots
  • Supramolecular dendrimers
  • Emulsion polymerization of nanoparticules
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