Università degli Studi di Milano

Foto_Anna-Bernardi_UMIL copia


Anna Bernardi

Dipartimento di Chimica
Università degli Studi di Milano (Milan, Italy)


Laura Medve


Laura Medve
University of Milan Fellow

Project: “Synthesis of glycomimetics library”



Our group is using chemical knowledge and computational techniques to design and synthesize sugar mimics, based on known structural properties of bioactive oligosaccharides and of their protein complexes. Our approach is based on the observation that many bioactive oligosaccharides can be dissected into one relatively small pharmacophoric portion which actually interacts with the biological target, and one large seemingly inactive scaffold formed by the oligosaccharide backbone, which appears to be holding the pharmacophore in place for appropriate interaction. We seek to simplify these structures by replacing their complex scaffolds with simpler molecules designed to maintain the required orientation of the pharmacophoric portion and to improve the metabolic stability of the resulting construct. In this way we hope to build so-called “drug-like” properties in our glycomimetics, and make them useful as potential drugs.