Consejo Superior de Investigaciones Científicas
Antonio Di Maio
IIQ – CSIC Fellow
Project: “Synthesis of glyco-dendrons and dendrimers as multivalent systems for functional studies”
The Glycosystems Laboratory is part of the Institute for Chemical Research (IIQ) at the Spanish National Research Council (CSIC), the biggest public research institution in Spain. Our main goal is the study in detail of the biologically relevant recognition processes involving carbohydrates. In particular, this laboratory is focused on the synthesis of carbohydrates, glycoconjugates, and carbohydrate multivalent systems, the structural elucidation of these entities using Nuclear Magnetic Resonance (NMR) and computational techniques, and the analysis of the interactions of these carbohydrate systems with their corresponding receptors using NMR together with different complementary approaches.
This laboratory has a large experience in the preparation of carbohydrate multivalent systems based on dendritic scaffolds. We have developed a convergent synthetic strategy to address the preparation of glycodendrons conveniently functionalized at the focal position to be conjugated with different scaffolds and platforms as well as biomolecules such as nucleic acids or peptides. These systems will be useful tools to be applied on glycobiology and biomedicine. In particular, they will be used to understand and intervene in biological processes related with immune modulation and pathogen infection.