On-chip screening of a glycomimetic library with C-type lectins reveals structural features responsible for preferential binding of dectin-2 over DC-SIGN/R and langerin

Medve, L; Achilli, S; Serna, S; Zuccotto, F; Varga, N; Thépaut, M; Civera, M; Vivès, C; Fieschi, F; Reichardt, N; Bernardi, A.

Chem. Eur. J. 2018, 24, 14448 – 14460

A library of mannose- and fucose-based glycomimetics was synthesized and screened in a microarray format against a set of C-type lectin receptors (CLRs) that included DC-SIGN, DC-SIGNR, langerin, and dectin-2. Glycomimetic ligands able to interact with dectin-2 were identified for the
first time. Comparative analysis of binding profiles allowed their selectivity against other CLRs to be probed.

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