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University of Veterinary Medicine (TiHo) Hannover

Bernd_Lepenies

 

Bernd Lepenies

Infection Immunology
University of Veterinary Medicine (TiHo) Hannover 

bernd.lepenies@tiho-hannover.de

 

 

Joao Monteiro

 

Joao Monteiro
TiHo Fellow
joao.monteiro@tiho-hannover.de

Project: “Carbohydrate immunomodulators targeting C-type lectin receptors on antigen-presenting cells”

 

The Infection Immunology group at the Research Center of Emerging Infections and Zoonoses (RIZ), TiHo Hannover, focuses on the role of C-type lectin receptors (CLRs) in infection and inflammation. CLRs represent a large lectin receptor superfamily predominantly expressed by cells of the innate immune system. CLRs recognize conserved glycan structures on pathogens and play a crucial role in the initiation of immune responses. In our group, the function of CLRs is investigated by using murine models of infection and autoimmunity. We intend to identify novel carbohydrate ligands of CLRs and utilize CLRs to target antigen-presenting cells. Finally, we aim to get a deeper understanding of how CLRs influence inflammatory processes in vivo.

Specifically, we address the following topics:
• Identification of novel CLR ligands on pathogens by glycan/glycoprotein array
• Targeting of CLRs on antigen-presenting cells using carbohydrate ligands
• Investigation of CLR functions in animal models of infection and autoimmunity.